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CKD-EPI (2021) Creatinine + Cystatine C calculator

CKD-EPI (2021) Creat. + Cys C

CKD-EPI stands for Chronic Kidney Disease Epidemiology Collaboration and it was developed to improve the accuracy of eGFR calculation over the previous formulas like MDRD and Cockcroft-Gault, especially in the general population and in those with mild to moderate kidney dysfunction.

A CKD-EPI calculator is a tool that uses the creatinine and/or cystatin C levels in a person's blood to estimate their glomerular filtration rate (eGFR), which is a measure of kidney function. The calculator uses mathematical equations to determine the eGFR based on the person's creatinine and/or cystatin C level, age, gender, and race. The eGFR is then used to classify the person's kidney function into one of five stages, with stage 1 indicating normal kidney function and stage 5 indicating end-stage kidney disease.

Both creatinine and cystatin C are used to calculate the estimated glomerular filtration rate (eGFR), which is an indicator of kidney function. Creatinine, a waste product produced by muscle metabolism, is commonly used to measure kidney function, but its levels can be affected by muscle mass and age. Cystatin C, a protein produced by all nucleated cells, is not affected by muscle mass and has been shown to be a more accurate marker of kidney function, particularly in older adults or those with low muscle mass.

Therefore, using both creatinine and cystatin C in combination can provide a more accurate assessment of kidney function and help identify chronic kidney disease (CKD) earlier.

Last update: 22 Jan 2023 04:24

References

1. Estimating Glomerular Filtration Rate from Serum Creatinine and Cystatin C. Lesley A Inker, Christopher H Schmid et al.. N. Engl. J. Med, 367, 2012

2. Utilizing Longitudinal Within-Individual Changes of Serum Creatinine, Cystatin C, and/or eGFR to Optimize Clinical Sensitivity and Eliminate Race and Gender Corrections. John G. Toffaletti, Cyril O. Burke et al.. The Journal of Applied Laboratory Medicine, 7, 3, 5 2022

3. Cystatin C-Properties and use as a diagnostic marker. Anders O. Grubb. Advances in Clinical Chemistry, 35, 1 2001

4. Detection of Chronic Kidney Disease With Creatinine, Cystatin C, and Urine Albumin-to-Creatinine Ratio and Association With Progression to End-Stage Renal Disease and Mortality. Carmen A. Peralta, Michael G. Shlipak et al.. JAMA, 305, 15, 4 2011

5. The definition, classification, and prognosis of chronic kidney disease: A KDIGO Controversies Conference report. Andrew S. Levey, Paul E. De Jong et al.. Kidney International, 80, 1, 2011

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Lesson authors: Dr. Mironescu Olivier, Dr. Huțuleac Oana Mihaela

Published on: 22 Jan 2023 04:24

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CKD-EPI stands for Chronic Kidney Disease Epidemiology Collaboration and it was developed to improve the accuracy of eGFR calculation over the previous formulas like MDRD and Cockcroft-Gault, especially in the general population and in those with mild to moderate kidney dysfunction.

A CKD-EPI calculator is a tool that uses the creatinine and/or cystatin C levels in a person's blood to estimate their glomerular filtration rate (eGFR), which is a measure of kidney function. The calculator uses mathematical equations to determine the eGFR based on the person's creatinine and/or cystatin C level, age, gender, and race. The eGFR is then used to classify the person's kidney function into one of five stages, with stage 1 indicating normal kidney function and stage 5 indicating end-stage kidney disease.

Both creatinine and cystatin C are used to calculate the estimated glomerular filtration rate (eGFR), which is an indicator of kidney function. Creatinine, a waste product produced by muscle metabolism, is commonly used to measure kidney function, but its levels can be affected by muscle mass and age. Cystatin C, a protein produced by all nucleated cells, is not affected by muscle mass and has been shown to be a more accurate marker of kidney function, particularly in older adults or those with low muscle mass.

Therefore, using both creatinine and cystatin C in combination can provide a more accurate assessment of kidney function and help identify chronic kidney disease (CKD) earlier.

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