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CKD-EPI (2021) Cystatin C equation

CKD-EPI (2021) Cystatin C eq.

Cystatin C is a protein that is produced by all nucleated cells in the body. It is a member of the cystatin family of proteins, which are known for their ability to inhibit cysteine proteases. The primary function of cystatin C is to control the activity of certain enzymes that are involved in breaking down proteins. Elevated levels of cystatin C in the blood have been associated with kidney disease, while decreased levels have been linked to certain neurological disorders. Additionally, cystatin C is also used as a marker for GFR (glomerular filtration rate) which is a measure of kidney function.

Cystatin C is used as part of the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation to estimate glomerular filtration rate (GFR), which is a measure of kidney function. This equation is used to determine the stage of chronic kidney disease (CKD) a person is in, and to monitor changes in GFR over time.

One of the reasons cystatin C is used in the CKD-EPI equation is because it is a more accurate marker of kidney function than creatinine, which is the traditional marker used to estimate GFR. Cystatin C is not affected by muscle mass, diet, or other factors that can affect creatinine levels, making it a more reliable indicator of kidney function. Additionally, cystatin C is more stable in blood and can be measured more easily.

CKD-EPI equation uses cystatin C along with creatinine, age, sex, race, and other factors to estimate GFR, which is a better representation of kidney function than creatinine alone.

The accuracy of CKD-EPI calculations when using Cystatin C can be as high as 90%, compared with the Cockcroft-Gault Equation which has a typical accuracy of 85% or when using creatinine alone as a variable (~70% accuracy)

Last update: 22 Jan 2023 01:36

References

1. Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2 diabetic patients. Michele Mussap, Michele Dalla Vestra et al.. Kidney international, 61, 4, 2002

2. Cystatin C: current position and future prospects; Sophie Séronie-Vivien, Pierre Delanaye et al.; Clinical chemistry and laboratory medicine, 46, 12, 12 2008

3. New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race. Lesley A. Inker, Nwamaka D. Eneanya et al.. New England Journal of Medicine, 385, 19, 11 2021

4. Performance of the 2021 Race-Free CKD-EPI Creatinine- and Cystatin C-Based Estimated GFR Equations Among Kidney Transplant Recipients. Gregory L. Hundemer, Christine A. White et al.. American journal of kidney diseases : the official journal of the National Kidney Foundation, 80-4

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Lesson authors: Dr. Mironescu Olivier, Dr. Huțuleac Oana Mihaela

Published on: 22 Jan 2023 01:36

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Cystatin C is a protein that is produced by all nucleated cells in the body. It is a member of the cystatin family of proteins, which are known for their ability to inhibit cysteine proteases. The primary function of cystatin C is to control the activity of certain enzymes that are involved in breaking down proteins. Elevated levels of cystatin C in the blood have been associated with kidney disease, while decreased levels have been linked to certain neurological disorders. Additionally, cystatin C is also used as a marker for GFR (glomerular filtration rate) which is a measure of kidney function.

Cystatin C is used as part of the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation to estimate glomerular filtration rate (GFR), which is a measure of kidney function. This equation is used to determine the stage of chronic kidney disease (CKD) a person is in, and to monitor changes in GFR over time.

One of the reasons cystatin C is used in the CKD-EPI equation is because it is a more accurate marker of kidney function than creatinine, which is the traditional marker used to estimate GFR. Cystatin C is not affected by muscle mass, diet, or other factors that can affect creatinine levels, making it a more reliable indicator of kidney function. Additionally, cystatin C is more stable in blood and can be measured more easily.

CKD-EPI equation uses cystatin C along with creatinine, age, sex, race, and other factors to estimate GFR, which is a better representation of kidney function than creatinine alone.

The accuracy of CKD-EPI calculations when using Cystatin C can be as high as 90%, compared with the Cockcroft-Gault Equation which has a typical accuracy of 85% or when using creatinine alone as a variable (~70% accuracy)

ckd, epi, calculator, medical, creatinine, cystatin, equation, 2021CKD-EPI (2021) Cystatin C equationCKD-EPI (2021) Cystatin C eq.0000