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CKD-EPI (2021) Creatinine equation

CKD-EPI (2021) Creatinine eq.

The CKD-EPI formula is a tool used to estimate the level of kidney function in patients with chronic kidney disease (CKD). It was updated in 2021 to provide more accurate results and improve the accuracy of stage classification for patients with CKD. The formula uses a patient's serum creatinine, age, sex, and race/ethnicity to calculate an estimated glomerular filtration rate (eGFR), which is a measure of kidney function.

Sure, the CKD-EPI formula was first introduced in 2009 as an alternative to the older MDRD formula. The new 2021 version, the CKD-EPI creatinine-cystatin C equation, is based on data from a large, diverse population and is intended to improve the accuracy of eGFR calculations in certain subgroups, such as older adults, people with low muscle mass, and those of certain races/ethnicities.

The new formula takes into account both serum creatinine and cystatin C, which is a protein that is produced at a constant rate in the body and is a marker of kidney function. By including cystatin C, the new formula is better able to account for variations in muscle mass and other factors that can affect creatinine levels, resulting in more accurate eGFR calculations.

Last update: 22 Jan 2023 00:42

References

1. Effects of the 2021 CKD-EPI Creatinine eGFR Equation among a National US Veteran Cohort. L. Parker Gregg, Peter A. Richardson et al.. Clinical Journal of the American Society of Nephrology, 17, 2, 2 2022

2. A new equation to estimate glomerular filtration rate. Andrew S. Levey, Lesley A. Stevens et al.. Annals of internal medicine, 150, 9, 5 2009

3. Performance of the 2021 Race-Free CKD-EPI Creatinine- and Cystatin C–Based Estimated GFR Equations Among Kidney Transplant Recipients Gregory L. Hundemer, Christine A. White et al. American Journal of Kidney Diseases, 80, 4, 10 2022

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Lesson authors: Dr. Mironescu Olivier, Dr. Huțuleac Oana Mihaela

Published on: 22 Jan 2023 00:42

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The CKD-EPI formula is a tool used to estimate the level of kidney function in patients with chronic kidney disease (CKD). It was updated in 2021 to provide more accurate results and improve the accuracy of stage classification for patients with CKD. The formula uses a patient's serum creatinine, age, sex, and race/ethnicity to calculate an estimated glomerular filtration rate (eGFR), which is a measure of kidney function.

Sure, the CKD-EPI formula was first introduced in 2009 as an alternative to the older MDRD formula. The new 2021 version, the CKD-EPI creatinine-cystatin C equation, is based on data from a large, diverse population and is intended to improve the accuracy of eGFR calculations in certain subgroups, such as older adults, people with low muscle mass, and those of certain races/ethnicities.

The new formula takes into account both serum creatinine and cystatin C, which is a protein that is produced at a constant rate in the body and is a marker of kidney function. By including cystatin C, the new formula is better able to account for variations in muscle mass and other factors that can affect creatinine levels, resulting in more accurate eGFR calculations.

ckd, epi, creatinine, 2021, kidney, nephrology, medical, calculator, chronicCKD-EPI (2021) Creatinine equationCKD-EPI (2021) Creatinine eq.0000